Eating a High-Fat Diet During Pregnancy Could Lower Offspring’s Alzheimer’s Risk, Study in Mice Suggests

Eating a high-fat food regimen throughout being pregnant may forestall offspring from creating Alzheimer’s illness later in life, in keeping with scientists who studied mice.

Scientists fed pregnant mice high-fat diets, and gave a management group a daily food regimen of chow. After they gave beginning, the mice had been switched to a typical chow food regimen as they breastfed. Their infants got common chow.

The staff examined the reminiscence and spatial studying skills of the offspring once they reached the age of 11 months and indicators linked to Alzheimer’s illness such because the build-up of amyloid beta amino acids, in addition to how properly their synapses (the hole between two nerve cells the place impulses cross) labored.

The high-fat food regimen appeared to protect the reminiscence of the mice, in addition to the functioning of their synapses. It was additionally linked to much less of a build-up of amyloid beta.

The regime appeared to show off three genes linked to Alzheimer’s illness, by boosting the exercise of the FOXP2 protein.

Eating a high-fat food regimen throughout being pregnant seems to guard offspring towards creating Alzheimer’s illness, the authors concluded of their paper printed within the journal Molecular Psychiatry. Such a food regimen might be use to forestall Alzheimer’s illness, they mentioned.

Senior creator Professor Domenico Praticò, Director of the Alzheimer’s Center at Temple on the Lewis Katz School of Medicine, commented in a press release: “Our findings suggest that, to be effective, Alzheimer’s disease prevention probably needs to start very early in life, during gestation.

“Diet at this particular life stage can have vital, however underestimated, long-term impacts on mind well being.”

However, as the study was carried out in rodents, it doesn’t mean the same effect would necessarily be seen in humans.

Praticò told Newsweek: “Our authentic speculation was the excessive fats food regimen throughout being pregnant would have a damaging impact on mind well being of the offspring, which was based mostly on the ample literature exhibiting that certainly direct publicity to a excessive fats food regimen has a damaging affect. Obviously we had been completely flawed!”

Next, the team will compare the potential benefits high-fat diets with others such as the Mediterranean diet, as well as those high in sugar and protein. They also want to see if they can replicate the findings in animals as they are found in the wild, rather than bred for labs.

avocado toast, cheese, stock, getty, snack,
A inventory picture of a girl consuming avocado and cheese on toast. Researchers have investigated the advantages of pregnant mice consuming high-fat diets.

As we do not at present know what causes Alzheimer’s illness, and there’s due to this fact no treatment, scientists are looking for methods to forestall the situation.

Earlier this 12 months, a separate staff of researchers in Canada and the U.Ok. checked out whether or not consuming a high-fat food regimen in adolescence raised the chance of creating Alzheimer’s later in life. The scientists concluded that weight problems attributable to consuming a high-fat food regimen may worsen mind injury and reminiscence issues attribute of Alzheimer’s illness. The findings had been printed within the journal NeuroImage: Clinical.

Evidence suggests the Mediterranean food regimen, which is wealthy in greens, fruit, and grains and comprises average ranges of oily fish and dairy however is low in crimson meat, saturated fats and sugar, may decrease an individual’s threat of creating dementia, of which Alzheimer’s is the commonest type.

This article has been up to date with remark from Domenico Praticò.

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